BBS7 Rabbit Polyclonal Antibody (CAB17718)
- SKU:
- CAB17718
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | BBS7 Rabbit Polyclonal Antibody |
SKU: | CAB17718 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human BBS7 (NP_060660.2). |
Sequence: | MDLI LNRM DYLQ VGVT SQKT MKLI PASR HRAT QKVV IGDH DGVV MCFG MKKG EAAA VFKT LPGP KIAR LELG GVIN TPQE KIFI AAAS EIRG FTKR GKQF LSFE TNLT ESIK AMHI SGSD LFLS ASYI YNHY CDCK DQHY YLSG DKIN DVIC LPVE RLSR ITPV LACQ DRVL RVLQ GSDV MYAV EVPG PPTV LALH NGNG GDSG EDLL FGTS DGKL ALIQ ITTS KPVR KWEI QNEK KRGG ILCI DSFD IVGD GVKD LLVG RDDG MVEV YS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BBS2L1; BBS7 |
Positive Sample: | Rat testis,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | axoneme, BBSome, centrosome, ciliary basal body, ciliary membrane, cytosol, nucleus |
Calculated MW: | 80kDa |
Observed MW: | 80kDa |
This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 55212 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |