The BBS7 Polyclonal Antibody (CAB17718) is a powerful tool for research involving the BBS7 protein, a key player in the BBSome complex responsible for ciliary trafficking. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By specifically binding to the BBS7 protein, researchers can easily detect and analyze this important molecule in various cell types.BBS7 is crucial for ciliary function and plays a role in various cellular processes, including protein trafficking and signaling pathways. Dysregulation of BBS7 has been linked to ciliary-related disorders such as Bardet-Biedl syndrome, making it a promising target for research in the field of ciliopathies.
Understanding the function of BBS7 is essential for unraveling the complexities of ciliary biology and developing potential therapies for ciliary-related diseases.Overall, the BBS7 Polyclonal Antibody is a valuable asset for studies in cell biology, ciliary biology, and genetic disorders. Its specificity and reliability make it a trusted tool for researchers looking to explore the intricate mechanisms of ciliary trafficking and related disorders.
Product Name:
BBS7 Rabbit Polyclonal Antibody
SKU:
CAB17718
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human BBS7 (NP_060660.2).
This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
55212
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BBS7 Rabbit pAb (CAB17718) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
