BBS10 Rabbit Polyclonal Antibody (CAB8820)
- SKU:
- CAB8820
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | BBS10 Rabbit Polyclonal Antibody |
SKU: | CAB8820 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 474-723 of human BBS10 (NP_078961.3). |
Sequence: | AENK DALE KTQT YLKV HSNL VIPD VELE TYIP YSTP TLTP TDTF QTVE TLTC LSLE RNRL TDYY EPLL KNNS TAYS TRGN RIEI SYEN LQVT NITR KGSM LPVS CKLP NMGT SQSY LSSS MPAG CVLP VGGN FEIL LHYY LLNY AKKC HQSE ETMV SMII ANAL LGIP KVLY KSKT GKYS FPHT YIRA VHAL QTNQ PLVS SQTG LESV MGKY QLLT SVLQ CLTK ILTI DMVI TVKR HPQK VHNQ DSED EL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:3000 |
Synonyms: | C12orf58; BBS10 |
Positive Sample: | A-549,A-431,HT-1080,HeLa,HepG2,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, cilium. |
Calculated MW: | 81kDa |
Observed MW: | 80kDa |
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10.
Purification Method: | Affinity purification |
Gene ID: | 79738 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |