PUMA Rabbit Polyclonal Antibody (CAB17138)
- SKU:
- CAB17138
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PUMA Rabbit Polyclonal Antibody |
SKU: | CAB17138 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-131 of human PUMA (NP_001120713.1). |
Sequence: | PGAL AGGP TQAA PGVR GEEE QWAR EIGA QLRR MADD LNAQ YERR RQEE QQRH RPSP WRVL YNLI MGLL PLPR GHRA PEME PN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | JFY1; PUMA; JFY-1 |
Positive Sample: | A-549,LO2,HepG2,K562 |
Cellular Localization: | Mitochondrion. |
Calculated MW: | 10kDa/14kDa/20kDa/26kDa |
Observed MW: | 20kDa |
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 27113 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |