BBC3 Antibody (PACO01380)
- SKU:
- PACO01380
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
BBC3 Antibody (PACO01380)
The BBC3 Polyclonal Antibody (PAC001380) is a valuable tool for researchers studying BBC3, a protein involved in apoptosis and cell death pathways. This antibody, generated in rabbits, exhibits high reactivity specifically with human samples and has been validated for use in Western blot applications. By binding to the BBC3 protein, this antibody allows for the detection and analysis of BBC3 expression in a variety of cell types, making it well-suited for investigations in cancer biology and cell signaling pathways.BBC3, also known as Bcl-2 Binding Component 3, plays a crucial role in regulating programmed cell death and is implicated in various cellular processes such as DNA damage response and apoptosis induction.
The involvement of BBC3 in key pathways associated with cell survival and death makes it a promising target for research in cancer therapeutics and drug development. By elucidating the mechanisms by which BBC3 functions, researchers can gain valuable insights into potential strategies for targeting cancer cells and improving treatment outcomes.
| Antibody Name: | BBC3 Antibody |
| Antibody SKU: | PACO01380 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human PUMA. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis |
| UniProt Protein Function: | PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol Molecular Function:protein binding Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; determination of adult life span; response to DNA damage stimulus; negative regulation of growth |
| NCBI Summary: | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9BXH1 |
| NCBI GenInfo Identifier: | 56748610 |
| NCBI Gene ID: | 27113 |
| NCBI Accession: | Q9BXH1.1 |
| UniProt Secondary Accession: | Q9BXH1,O00171, Q96PG9, B9EGI3, |
| UniProt Related Accession: | Q96PG8,Q9BXH1 |
| Molecular Weight: | 193 |
| NCBI Full Name: | Bcl-2-binding component 3 |
| NCBI Synonym Full Names: | BCL2 binding component 3 |
| NCBI Official Symbol: | BBC3Â Â |
| NCBI Official Synonym Symbols: | JFY1; PUMA; JFY-1Â Â |
| NCBI Protein Information: | bcl-2-binding component 3; p53 up-regulated modulator of apoptosis |
| UniProt Protein Name: | Bcl-2-binding component 3 |
| UniProt Synonym Protein Names: | JFY-1; p53 up-regulated modulator of apoptosis |
| Protein Family: | Bcl-2-binding component |
| UniProt Gene Name: | BBC3Â Â |
| UniProt Entry Name: | BBC3_HUMAN |
Related Products
BBC3 Antibody (PACO17630)
BBC3 Antibody (PACO17629)
BBC3 Antibody (PACO63199)
BBC3 Antibody (PACO21344)
Rat Bcl-2-binding component 3 (Bbc3) ELISA Kit (RTEB1268)
Rat PUMA / BBC3 / P53 Upregulated Modulator of Apoptosis ELISA Kit
