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Anti-Bax Antibody (CAB7626)

SKU:
CAB7626
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-Bax Antibody CAB7626
  • Cell Death Antibodies 2 Anti-Bax Antibody CAB7626
€139 - €419
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Description

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Anti-Bax Antibody (CAB7626)

The Bax Polyclonal Antibody (CAB7626) is a versatile tool for researchers studying the Bax protein, a key regulator of apoptosis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Bax protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology, cancer research, and drug development.Bax is a pro-apoptotic protein that plays a crucial role in programmed cell death, influencing the balance between cell survival and cell death.

Dysregulation of Bax is associated with various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. By delving into the mechanisms of Bax signaling, researchers can uncover new insights into disease pathogenesis and potentially develop novel treatments to combat these conditions.

Antibody Name:Anti-Bax Antibody
Antibody SKU:CAB7626
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Bax (NP_620116.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:MCF7, SW620, HepG2, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Bax (NP_620116.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDGS GEQP RGGG PTSS EQIM KTGA LLLQ GFIQ DRAG RMGG EAPE LALD PVPQ DAST KKLS ECLK RIGD ELDS NMEL QRMI AAVD TDSP REVF FRVA ADMF
Gene ID:581
Uniprot:Q07812
Cellular Location:Cytoplasm, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein
Calculated MW:4kDa/12kDa/15kDa/18kDa/19kDa/21kDa/24kDa
Observed MW:21kDa
Synonyms:BCL2L4, BAX
Background:The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
UniProt Protein Function:Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
NCBI Summary:The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q07812
NCBI GenInfo Identifier:728945
NCBI Gene ID:581
NCBI Accession:Q07812.1
UniProt Secondary Accession:Q07812,P55269, Q07814, Q07815, Q8WZ49, Q9NR76, Q9NYG7 Q9UCZ6, Q9UCZ7, Q9UQD6, A8K4W1,
UniProt Related Accession:Q07812
Molecular Weight:19,718 Da
NCBI Full Name:Apoptosis regulator BAX
NCBI Synonym Full Names:BCL2 associated X, apoptosis regulator
NCBI Official Symbol:BAX  
NCBI Official Synonym Symbols:BCL2L4  
NCBI Protein Information:apoptosis regulator BAX
UniProt Protein Name:Apoptosis regulator BAX
UniProt Synonym Protein Names:Bcl-2-like protein 4; Bcl2-L-4
Protein Family:Protein
UniProt Gene Name:BAX  
UniProt Entry Name:BAX_HUMAN
Anti-Bax Antibody (CAB7626)Western blot analysis of extracts of various cell lines, using Bax antibody (CAB7626) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-Bax Antibody (CAB7626)Immunofluorescence analysis of L929 cells using Bax Rabbit pAb (CAB7626) at dilution of 1:100. Blue: DAPI for nuclear staining.

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