The Battenin Polyclonal Antibody (CAB1931) is a valuable tool for researchers studying Batten disease, a rare and fatal neurodegenerative disorder that primarily affects children. This antibody, generated in rabbits, is highly specific for detecting the battenin protein in human samples, making it ideal for applications such as immunohistochemistry and immunofluorescence.Battenin, encoded by the CLN3 gene, plays a crucial role in lysosomal function and has been linked to the accumulation of lipopigments in various tissues, leading to the characteristic symptoms of Batten disease.
By using the CAB1931 antibody, researchers can visualize the expression and localization of battenin in cells and tissues, providing insights into the molecular mechanisms underlying this devastating condition.With its high specificity and sensitivity, the Battenin Polyclonal Antibody (CAB1931) is a valuable tool for furthering our understanding of Batten disease and may pave the way for the development of novel diagnostic and therapeutic strategies for this devastating disorder.
Product Name:
CLN3 Rabbit Polyclonal Antibody
SKU:
CAB1931
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CLN3 (NP_001035897.1).
Late endosome, Lysosome membrane, Multi-pass membrane protein.
Calculated MW:
48kDa
Observed MW:
48kDa
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1201
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLN3 Rabbit pAb (CAB1931) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
