The BATF3 Monoclonal Antibody (PAC025212) is a valuable tool for researchers studying BATF3, a transcription factor essential for the development of specific immune cell populations. This antibody, produced in mice, is highly specific and shows strong reactivity with human samples, making it suitable for various applications including Western blot and immunohistochemistry.BATF3 is a key regulator of dendritic cell development and function, playing a crucial role in immune responses against pathogens and in antitumor immunity.
Research on BATF3 has implications for understanding immune cell diversity and immune regulation in the context of infection, cancer, and autoimmune diseases. The use of this antibody enables precise detection and analysis of BATF3 protein expression in different cell types, facilitating further investigations in immunology and cancer research.
Antibody Name:
Batf3 Antibody (PACO25212)
Antibody SKU:
PACO25212
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Basic leucine zipper transcriptional factor ATF-like 3 protein (1-133AA)
AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity).
BATF3: Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12- O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities. Belongs to the bZIP family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 1q32.3Cellular Component: nucleusMolecular Function: protein binding; transcription corepressor activity; transcription factor activityBiological Process: myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; response to virus; transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
