The BATF2 Polyclonal Antibody (PACO38226) is a valuable tool for researchers studying BATF2, a transcription factor known for its role in immune regulation and cancer development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the BATF2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and oncology research.BATF2, or Basic Leucine Zipper ATF-Like Transcription Factor 2, is a key player in regulating immune responses and controlling the expression of genes involved in inflammation and anti-tumor immunity.
Researchers studying BATF2 are interested in its potential therapeutic applications in cancer treatments, autoimmune diseases, and inflammatory conditions. Understanding the mechanisms by which BATF2 functions is essential for developing targeted therapies that manipulate immune responses for therapeutic benefit.Overall, the BATF2 Polyclonal Antibody offers researchers a reliable tool for studying the complex roles of BATF2 in immune regulation and cancer biology, providing valuable insights for the development of novel therapies targeting immune-related diseases.
Antibody Name:
BATF2 Antibody (PACO38226)
Antibody SKU:
PACO38226
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 protein (1-189AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO38226 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO38226 at dilution of 1:100.
Background:
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.
Synonyms:
Basic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI), BATF2
UniProt Protein Function:
BATF2: Belongs to the bZIP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 11q13.1Cellular Component: nucleusMolecular Function: protein bindingBiological Process: defense response to protozoan; myeloid dendritic cell differentiation
