The Barttin Polyclonal Antibody (CAB7747) is a valuable tool for researchers studying the Barttin protein, a critical component of chloride channels involved in electrolyte transport and kidney function. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Barttin protein, researchers can detect and analyze its expression in various cell types, making it ideal for investigations in nephrology and renal physiology.Barttin, a beta subunit of chloride channels, plays a crucial role in maintaining chloride ion transport across cell membranes, particularly in the kidneys.
Dysregulation of Barttin function has been implicated in various kidney disorders, including Bartter syndrome and Gitelman syndrome. Therefore, understanding the role of Barttin in electrolyte balance and kidney function is essential for developing treatments for these conditions.By utilizing the Barttin Polyclonal Antibody, researchers can further elucidate the functions and mechanisms of Barttin in kidney physiology and pathology, paving the way for potential therapeutic interventions targeting Barttin-related disorders.
Product Name:
BSND Rabbit Polyclonal Antibody
SKU:
CAB7747
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 54-320 of human BSND (NP_476517.1).
This gene encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear. Mutations in this gene have been associated with Bartter syndrome with sensorineural deafness.
Purification Method:
Affinity purification
Gene ID:
7809
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BSND antibody (CAB7747) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
