The BARD1 Polyclonal Antibody (PACO00455) is a valuable tool for researchers studying the BARD1 protein, which plays a crucial role in DNA repair and tumor suppression. This antibody, produced in rabbits, is highly specific to human BARD1 and has been validated for use in Western blot applications.BARD1 is a key player in the BRCA1/BARD1 tumor suppressor complex, which is essential for maintaining genomic stability and preventing the development of cancer. Mutations in BARD1 have been implicated in a variety of cancers, making it a promising target for cancer research and drug development.
By using the BARD1 Polyclonal Antibody, researchers can easily detect and analyze BARD1 protein levels in various cell types, providing valuable insights into its function in DNA repair and cancer development. This antibody is an essential tool for any study focusing on BARD1 and its role in tumor suppression, making it a valuable addition to any immunology or cancer research lab.
Antibody Name:
BARD1 Antibody
Antibody SKU:
PACO00455
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human BARD1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
BARD1; BRCA1-associated RING domain protein 1; BARD-1
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
