BAP1 Rabbit Polyclonal Antibody (CAB6533)
- SKU:
- CAB6533
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | BAP1 Rabbit Polyclonal Antibody |
SKU: | CAB6533 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human BAP1 (NP_004647.1). |
Sequence: | MNKG WLEL ESDP GLFT LLVE DFGV KGVQ VEEI YDLQ SKCQ GPVY GFIF LFKW IEER RSRR KVST LVDD TSVI DDDI VNNM FFAH QLIP NSCA THAL LSVL LNCS SVDL GPTL SRMK DFTK GFSP ESKG YAIG NAPE LAKA HNSH ARPE PRHL PEKQ NGLS AVRT MEAF HFVS YVPI TGRL FELD GLKV YPID HGPW GEDE EWTD KARR VIME RIGL ATAG EPYH DIRF NLMA VVPD RRIK YEAR LHVL KVNR QTVL EALQ QLIR VTQP EL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | UBM2; UVM2; KURIS; TPDS1; UCHL2; hucep-6; HUCEP-13; BAP1 |
Positive Sample: | Mouse testis,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 80kDa |
Observed MW: | 95kDa |
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
Purification Method: | Affinity purification |
Gene ID: | 8314 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |