The BANK1 Polyclonal Antibody (CAB10312) is a valuable tool for researchers studying BANK1, a key protein involved in immune regulation and autoimmune diseases. This antibody, raised in rabbits, is specifically tailored to detect BANK1 in human samples and is validated for use in Western blot applications. By binding to the BANK1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for immunology and autoimmune research studies.BANK1, also known as B-cell scaffold protein with ankyrin repeats 1, plays a crucial role in B-cell receptor signaling and immune response modulation.
Dysregulation of BANK1 has been linked to autoimmune diseases such as lupus and rheumatoid arthritis, making it a promising target for therapeutic interventions. By understanding the function and regulation of BANK1, researchers can develop novel strategies for treating autoimmune disorders and other immune-related conditions. Overall, the BANK1 Polyclonal Antibody (CAB10312) offers researchers a reliable tool for investigating the role of BANK1 in immune regulation and autoimmune diseases, advancing our understanding of these complex conditions and potentially leading to the development of new treatments.
Product Name:
BANK1 Rabbit Polyclonal Antibody
SKU:
CAB10312
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 516-785 of human BANK1 (NP_060405.4).
B cells,Raji,U-87MG,A-549,22Rv1,HepG2,Mouse liver,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
perinuclear region of cytoplasm
Calculated MW:
89kDa
Observed MW:
89kDa
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55024
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BANK1 antibody (CAB10312) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
