The Banf1 Polyclonal Antibody (CAB14555) is a valuable tool for research involving Banf1, a protein involved in DNA replication and repair processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the Banf1 protein, this antibody allows for the detection and analysis of Banf1 in various cell types, making it ideal for studies in molecular biology and cancer research.Banf1, also known as Barrier-to-autointegration factor 1, is essential for maintaining the stability and organization of the nuclear envelope, as well as for proper chromosome segregation during cell division.
Dysregulation of Banf1 has been linked to cancer development and other diseases related to genomic instability. Therefore, studying the function and regulation of Banf1 is crucial for understanding its role in cellular processes and disease progression.Overall, the Banf1 Polyclonal Antibody is a reliable tool for researchers investigating the role of Banf1 in cellular processes and disease pathways, providing valuable insights into potential therapeutic targets for cancer and other genetic disorders.
Product Name:
BANF1 Rabbit Polyclonal Antibody
SKU:
CAB14555
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-89 of human BANF1 (NP_001137457.1).
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
8815
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BANF1 Rabbit pAb (CAB14555) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
