Bak Rabbit Polyclonal Antibody (CAB0204)
- SKU:
- CAB0204
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Bak Rabbit Polyclonal Antibody |
SKU: | CAB0204 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bak (NP_001179.1). |
Sequence: | EGVA APAD PEMV TLPL QPSS TMGQ VGRQ LAII GDDI NRRY DSEF QTML QHLQ PTAE NAYE YFTK IATS LFES GINW GRVV ALLG FGYR LALH VYQH GLTG F |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | BAK; CDN1; BCL2L7; BAK-LIKE; Bak |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion membrane, Single-pass membrane protein. |
Calculated MW: | 23kDa |
Observed MW: | 25kDa |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Purification Method: | Affinity purification |
Gene ID: | 578 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |