BAG3 Rabbit Monoclonal Antibody (CAB4720)
- SKU:
- CAB4720
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BAG-3
- BIS
- CAIR-1
- MFM6
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | BAG3 Rabbit Monoclonal Antibody |
SKU: | CAB4720 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human BAG3 (O95817). |
Sequence: | NDPR VPSE GPKE TPSS ANGP SREG SRLP PARE GHPV YPQL RPGY IPIP VLHE GAEN RQVH PFHV YPQP GMQR FRTE AAAA APQR SQSP LRGM PETT QPDK Q |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | BIS; MFM6; BAG-3; CAIR-1; BAG3 |
Positive Sample: | HeLa,K-562,U-251MG |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytosol, Nucleus, Z disc |
Calculated MW: | 62kDa |
Observed MW: | 74kDa |
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Purification Method: | Affinity purification |
Gene ID: | 9531 |
Clone Number: | ARC1104 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |