BAG3 Rabbit Polyclonal Antibody (CAB14826)
- SKU:
- CAB14826
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | BAG3 Rabbit Polyclonal Antibody |
SKU: | CAB14826 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-575 of human BAG3 (NP_004272.2). |
Sequence: | PSAV PSSP KSVA TEER AAPS TAPA EATP PKPG EAEA PPKH PGVL KVEA ILEK VQGL EQAV DNFE GKKT DKKY LMIE EYLT KELL ALDS VDPE GRAD VRQA RRDG VRKV QTIL EKLE QKAI DVPG QVQV YELQ PSNL EADQ PLQA IMEM GAVA ADKG KKNA GNAE DPHT ETQQ PEAT AAAT SNPS SMTD TPGN PAAP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | BIS; MFM6; BAG-3; CAIR-1; BAG3 |
Positive Sample: | A-549,HeLa,HepG2,Mouse brain,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleus, Z disc |
Calculated MW: | 62kDa |
Observed MW: | 80kDa |
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Purification Method: | Affinity purification |
Gene ID: | 9531 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |