The BAG3 Polyclonal Antibody (PAC040618) is a valuable tool for researchers studying BAG3, a protein involved in cell survival and stress response pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the BAG3 protein, researchers can analyze its expression and function in various cell types, providing insights into its role in cancer and other diseases.BAG3, a co-chaperone protein, is known for its ability to regulate cell death and protect cells from stress-induced damage.
Its involvement in cell signaling pathways and protein quality control mechanisms makes it a key player in maintaining cellular homeostasis. Research into BAG3’s functions is crucial for understanding how it contributes to diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. By studying BAG3 with this antibody, researchers can uncover new therapeutic targets and strategies for treating these illnesses.
Antibody Name:
Bag3 Antibody (PACO40618)
Antibody SKU:
PACO40618
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IP
Recommended Dilutions:
ELISA:1:2000-1:10000, IP:1:200-1:2000
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse BAG family molecular chaperone regulator 3 protein (2-577AA)
Immunoprecipitating Bag3 in K562 whole cell lysate. Lane 1: Rabbit control IgG (1µg) instead of PACO40618 in K562 whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000). Lane 2: PACO40618 (6µg) + K562 whole cell lysate (500µg). Lane 3: K562 whole cell lysate (10µg).
Background:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
Synonyms:
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis), Bag3, Bis
UniProt Protein Function:
Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.Subunit structure: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma By similarity. Interacts with DNAJB6 By similarity.Sequence similarities: Contains 1 BAG domain.Contains 2 WW domains.
