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BAG2 Monoclonal Antibody [PAT29E9AT] (CPAB0662)

SKU:
CPAB0662
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT29E9AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

BAG2 Monoclonal Antibody [PAT29E9AT] (CPAB0662)

The BAG2 Polyclonal Antibody (CPAB0662) is a valuable tool for researchers studying BAG2, a protein involved in regulating cellular stress responses and apoptosis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the BAG2 protein, this antibody allows for the detection and analysis of BAG2 expression in various cell types, making it an essential component for studies in cell biology and cancer research.BAG2, also known as Bcl-2-associated athanogene 2, plays a crucial role in protecting cells from stress-induced apoptosis and promoting cell survival.

Dysregulation of BAG2 expression has been implicated in various diseases, including cancer and neurodegenerative disorders, making it an attractive target for further investigation. Understanding the function of BAG2 can provide valuable insights into the mechanisms underlying these diseases and potentially lead to the development of novel therapeutic strategies.

Product Name:BAG2 Antibody
Product Sku:CPAB0662
Size:5μg
Host Species:Mouse
Immunogen:Anti-human BAG2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human BAG2 protein 1-211 amino acids purified from Ecoli.
Clone:PAT29E9AT.
Reactivity:Other bodies
Applications:ELISA, Flow Cytometry
Purification Method:BAG2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:BCL2-associated athanogene 2 (BAG2) belongs to the Bag family of proteins. BAG2 is a chief component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to upset CHIP-mediated ubiquitylation. BAG proteins compete with Hip for attaching to the Hsc70/Hsp70 ATPase domain and promote substrate discharge. All the BAG proteins have a roughly 45 amino acid BAG domain by the C-terminus but vary clearly in their N-terminal regions. The BAG domains of BAG1, BAG2, and BAG3 act together expressly with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins attach with high affinity to the ATPase domain of Hsc70 and obstruct its chaperone activity in a Hip-repressible manner.
Synonyms:BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2, KIAA0576, MGC149462, dJ417I1.2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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