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BAFF Monoclonal Antibody [PH4C7AT] (CPAB0064)

SKU:
CPAB0064
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG3
Clone:
PH4C7AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

BAFF Monoclonal Antibody [PH4C7AT] (CPAB0064)

The BAFF Polyclonal Antibody (CPAB0064) is a valuable tool for studying B-cell activating factor (BAFF), a cytokine that plays a crucial role in B-cell survival and maturation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the BAFF protein, researchers can accurately detect and analyze its expression in various cell types, paving the way for advancements in immunology and autoimmune disease research.BAFF is a key regulator of B-cell function, promoting their survival and differentiation, making it a promising therapeutic target for diseases like lupus, rheumatoid arthritis, and other autoimmune disorders.

By understanding the role of BAFF in immune dysregulation, researchers can develop targeted therapies that modulate B-cell activity, potentially leading to breakthroughs in the treatment of these conditions. The BAFF Polyclonal Antibody (CPAB0064) is a valuable tool for unraveling the complex mechanisms of BAFF signaling and its implications in disease pathogenesis.

Product Name:BAFF Antibody
Product Sku:CPAB0064
Size:5μg
Host Species:Mouse
Immunogen:Anti-human BAFF mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human BAFF amino acids 134-285 purified from Ecoli.
Clone:PH4C7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:BAFF antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG3
Background:Binds to tnfrsf13b/taci and tnfrsf17/bcma. tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response. B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays. Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin.
Synonyms:BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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