The BAD Polyclonal Antibody (CAB1593) is a reliable tool for researchers studying the BAD protein, a key regulator of apoptosis and cell survival. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the BAD protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in cell biology and cancer research.BAD, also known as Bcl-2-associated death promoter, is a crucial player in the control of apoptosis, or programmed cell death.
Dysregulation of BAD has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. By investigating the function and regulation of BAD, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.Overall, the BAD Polyclonal Antibody (CAB1593) offers researchers a reliable tool for studying the role of BAD in cell survival and apoptosis, advancing our understanding of disease pathology and potential treatment strategies.
Product Name:
Bad Rabbit Polyclonal Antibody
SKU:
CAB1593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bad (NP_004313.1).
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Purification Method:
Affinity purification
Gene ID:
572
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Bad Rabbit pAb (CAB1593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
