The BACH1 Polyclonal Antibody (CAB5393) is a high-quality research tool for studying the BACH1 protein, a transcription factor involved in the regulation of genes related to oxidative stress response and DNA damage repair. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.BACH1 is known to play a critical role in maintaining cellular homeostasis by controlling the expression of genes involved in antioxidant defense mechanisms and DNA repair processes. Dysregulation of BACH1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
With its specificity and reliability, the BACH1 Polyclonal Antibody is essential for researchers studying the molecular mechanisms underlying oxidative stress, DNA damage, and related pathways. By enabling the detection and analysis of BACH1 in various cell types and tissues, this antibody facilitates in-depth investigations into the role of BACH1 in health and disease, ultimately contributing to the development of novel therapeutic strategies.
Product Name:
BACH1 Rabbit Polyclonal Antibody
SKU:
CAB5393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human BACH1 (NP_996749.1).
WB,1:1000 - 1:5000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
BACH-1; BTBD24; BACH1
Positive Sample:
HEL,K-562
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
82kDa
Observed MW:
100-110kDa
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
571
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HEL cells, using BACH1 Rabbit pAb (CAB5393) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
