The BACE2 Polyclonal Antibody (CAB14864) is a vital tool for researchers studying BACE2, a key enzyme involved in the processing of amyloid precursor protein (APP) and implicated in Alzheimer's disease. This high-quality antibody, raised in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.BACE2, a close homolog of BACE1, plays a crucial role in the generation of amyloid-beta peptides, which are known to accumulate in the brains of Alzheimer's patients. By targeting BACE2 with this antibody, researchers can effectively detect and analyze BACE2 protein levels in various cell types, providing insights into its function and potential as a therapeutic target for Alzheimer's disease.
With the growing prevalence of Alzheimer's disease and the urgent need for effective therapies, the BACE2 Polyclonal Antibody offers a valuable tool for advancing our understanding of the disease and developing targeted treatments. Its specificity and reliability make it an essential component of research in neurobiology and neurodegenerative disorders.
Product Name:
BACE2 Rabbit Polyclonal Antibody
SKU:
CAB14864
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human BACE2 (NP_036237.2).
Cell surface, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein.
Calculated MW:
56kDa
Observed MW:
56kDa
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
25825
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from DU145 cells, using BACE2 Rabbit pAb (CAB14864) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
