The BACE1 Rabbit Monoclonal Antibody is a crucial tool for researchers studying BACE1, an enzyme central to the pathogenesis of Alzheimer's disease. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting BACE1 in human samples, making it suitable for use in various research applications, including Western blotting, immunofluorescence, and immunohistochemistry.BACE1, also known as beta-secretase, is involved in the cleavage of amyloid precursor protein, leading to the production of beta-amyloid peptides that accumulate in the brains of Alzheimer's patients.
Inhibition of BACE1 activity is a promising therapeutic strategy for the treatment of Alzheimer's disease, making this antibody an invaluable tool for drug discovery and preclinical research.By enabling the detection and analysis of BACE1 expression and localization in different cell types and tissues, this monoclonal antibody offers researchers a deeper understanding of the role of BACE1 in neurodegenerative diseases. Its high specificity and sensitivity ensure reliable and reproducible results, advancing our knowledge of Alzheimer's disease and potential therapeutic targets.
Product Name:
BACE1 Rabbit Monoclonal Antibody
SKU:
CAB11533
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 402-501 of human BACE1 (P56817).
Cell surface, Cytoplasmic vesicle membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Single-pass type I membrane protein, trans-Golgi network.
Calculated MW:
56kDa
Observed MW:
70kDa
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
Purification Method:
Affinity purification
Gene ID:
23621
Clone Number:
ARC0696
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BACE1 Rabbit mAb (CAB11533) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
