The B7-H4 (B7S1, B7x) Polyclonal Antibody is a crucial tool for researchers studying the B7-H4 protein, a member of the B7 family involved in immune regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the B7-H4 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential asset for studies in immunology and cancer research.B7-H4, also known as B7S1 or B7x, is a key regulator of immune responses, playing a significant role in maintaining immune homeostasis and suppressing inflammatory reactions.
Its importance in immune system modulation highlights its potential as a therapeutic target for conditions such as cancer, autoimmune diseases, and chronic inflammation. Investigation into the function of B7-H4 is crucial for the development of treatments that can modulate immune responses in these pathological contexts.
Product Name:
B7-H4 / B7S1 / B7x Polyclonal Antibody
SKU:
CAB24542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-259 of human B7-H4 / B7S1 / B7x (NP_078902.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
9kDa/18kDa/20kDa/30kDa
Observed MW:
75kDa
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79679
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse testis, using B7-H4 / B7S1 / B7x Rabbit pAb (CAB24542) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
