B4GALT7 Antibody (PACO52874)
- SKU:
- PACO52874
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
B4GALT7 Antibody (PACO52874)
The B4GALT7 Polyclonal Antibody (PAC052874) offered by AssayGenie is a valuable tool for researchers studying B4GALT7, a key enzyme involved in glycosylation processes. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it an excellent choice for Western blot applications. By binding to the B4GALT7 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in glycobiology and related fields.B4GALT7 plays a crucial role in the glycosylation pathway, influencing the structure and function of glycoproteins involved in numerous biological processes.
Dysregulation of B4GALT7 has been implicated in various diseases, including cancer and genetic disorders affecting development and growth. By studying B4GALT7 using this antibody, researchers can gain insight into its roles in health and disease, potentially leading to the development of targeted therapies or diagnostic tools targeting glycosylation-related pathways.
| Antibody Name: | B4GALT7 Antibody (PACO52874) |
| Antibody SKU: | PACO52874 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Beta-1,4-galactosyltransferase 7 protein (52-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: B4GALT7 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38 kDa. Observed band size: 38 kDa. |
| Background: | Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. |
| Synonyms: | Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) [Includes: Xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein beta-1,4-galactosyltransferase)], B4GALT7, XGALT1 |
| UniProt Protein Function: | B4GALT7: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. Defects in B4GALT7 are the cause of Ehlers-Danlos syndrome progeroid type (EDSP). EDSP is a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits. Belongs to the glycosyltransferase 7 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - chondroitin sulfate biosynthesis; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.4.1.133 Chromosomal Location of Human Ortholog: 5q35.2-q35.3 Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane Molecular Function:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; manganese ion binding; xylosylprotein 4-beta-galactosyltransferase activity; galactosyltransferase activity Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; proteoglycan metabolic process; glycosaminoglycan metabolic process; negative regulation of fibroblast proliferation; carbohydrate metabolic process; fibril organization and biogenesis; protein amino acid N-linked glycosylation; protein modification process; pathogenesis Disease: Ehlers-danlos Syndrome, Progeroid Type, 1 |
| NCBI Summary: | This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9UBV7 |
| NCBI GenInfo Identifier: | 13123990 |
| NCBI Gene ID: | 11285 |
| NCBI Accession: | Q9UBV7.1 |
| UniProt Secondary Accession: | Q9UBV7,Q9UHN2, B3KN39, |
| UniProt Related Accession: | Q9UBV7 |
| Molecular Weight: | 327 |
| NCBI Full Name: | Beta-1,4-galactosyltransferase 7 |
| NCBI Synonym Full Names: | xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 |
| NCBI Official Symbol: | B4GALT7Â Â |
| NCBI Official Synonym Symbols: | EDSP1; XGPT1; XGALT1Â Â |
| NCBI Protein Information: | beta-1,4-galactosyltransferase 7; beta4Gal-T7; beta4GalT-VII; beta-1,4-GalTase 7; galactosyltransferase I; beta-1,4-galactosyltransferase VII; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7 |
| UniProt Protein Name: | Beta-1,4-galactosyltransferase 7 |
| UniProt Synonym Protein Names: | UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7Including the following 1 domains:Xylosylprotein 4-beta-galactosyltransferase (EC:2.4.1.133)Alternative name(s):Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; XGPT; XGalT-1; Xylosylprotein beta-1,4-galactosyltransferase |
| Protein Family: | Beta-1,4-galactosyltransferase |
| UniProt Gene Name: | B4GALT7Â Â |
| UniProt Entry Name: | B4GT7_HUMAN |
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