The B4GALNT2 Polyclonal Antibody (PAC039962) is a valuable tool for researchers studying B4GALNT2, a glycosyltransferase enzyme involved in the biosynthesis of complex gangliosides. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in various research applications such as immunohistochemistry and Western blotting.B4GALNT2 is known for its role in catalyzing the transfer of sugar molecules to glycolipids, which play essential roles in cell signaling, adhesion, and membrane trafficking. Dysregulation of glycosylation processes, including those mediated by B4GALNT2, has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune-related conditions.
By utilizing the B4GALNT2 Polyclonal Antibody in their research, scientists can gain valuable insights into the function and regulation of B4GALNT2 in normal physiological processes and disease states. This antibody is a reliable tool for investigating the molecular mechanisms underlying glycosylation pathways and their implications in human health and disease.
Antibody Name:
B4GALNT2 Antibody (PACO39962)
Antibody SKU:
PACO39962
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Beta-1,4 N-acetylgalactosaminyltransferase 2 protein (301-566AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO39962 at dilution of 1:100.
Background:
Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.
Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain.
UniProt Protein Details:
NCBI Summary:
B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]
