Background: | Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. |
Synonyms: | Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase), B4GALNT2, GALGT2 |
UniProt Protein Function: | Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. |
UniProt Protein Details: | |
NCBI Summary: | B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8NHY0 |
NCBI GenInfo Identifier: | 227498224 |
NCBI Gene ID: | 124872 |
NCBI Accession: | NP_001152859.1 |
UniProt Secondary Accession: | Q8NHY0,Q14CP1, Q86Y40, B4DZE4 |
UniProt Related Accession: | Q8NHY0 |
Molecular Weight: | 62 |
NCBI Full Name: | beta-1,4 N-acetylgalactosaminyltransferase 2 isoform b |
NCBI Synonym Full Names: | beta-1,4-N-acetyl-galactosaminyltransferase 2 |
NCBI Official Symbol: | B4GALNT2Â Â |
NCBI Official Synonym Symbols: | B4GALT; GALGT2Â Â |
NCBI Protein Information: | beta-1,4 N-acetylgalactosaminyltransferase 2 |
UniProt Protein Name: | Beta-1,4 N-acetylgalactosaminyltransferase 2 |
UniProt Synonym Protein Names: | Sd(a) beta-1,4-GalNAc transferase; UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase |
Protein Family: | |
UniProt Gene Name: | B4GALNT2Â Â |
UniProt Entry Name: | |