The B3GALT6 Polyclonal Antibody (PACO07962) is a valuable tool for researchers studying B3GALT6, a key enzyme involved in glycosylation processes. This antibody, generated in rabbits, has been rigorously tested and proven to be highly specific for detecting B3GALT6 in human samples using Western blot techniques. By targeting the B3GALT6 protein, researchers can accurately assess its expression levels and activity in different cell types, making it an essential reagent for studies in glycobiology and cancer research.B3GALT6 plays a crucial role in the biosynthesis of glycosaminoglycans (GAGs), which are essential components of the extracellular matrix and cell surface proteins.
Dysregulation of B3GALT6 has been implicated in various diseases, including cancer and developmental disorders. By understanding the functions of B3GALT6, researchers can gain insights into the mechanisms underlying disease pathology and potentially identify new therapeutic targets for intervention.Overall, the B3GALT6 Polyclonal Antibody is a reliable tool for investigating the functions of B3GALT6 in biological processes and disease states. Its specificity and sensitivity make it an indispensable resource for researchers aiming to unravel the complex roles of glycosylation in health and disease.
B3GALT6: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues. Belongs to the glycosyltransferase 31 family.Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.134Chromosomal Location of Human Ortholog: 1p36.33Cellular Component: Golgi medial cisterna; Golgi membrane; membraneMolecular Function: galactosylxylosylprotein 3-beta-galactosyltransferase activity; UDP-galactosyltransferase activityBiological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic processDisease: Ehlers-danlos Syndrome, Progeroid Type, 2; Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 1, With Or Without Fractures
UniProt Protein Details:
NCBI Summary:
The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013]
