The B3GALT1 Polyclonal Antibody (PACO01738) is a valuable tool for researchers studying the B3GALT1 protein, which is involved in the biosynthesis of complex glycolipids and glycoproteins. This antibody, developed in rabbits, has high specificity for human samples and is optimized for use in Western blotting applications. By binding to the B3GALT1 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it ideal for investigations in glycobiology and cancer research.
B3GALT1 plays a crucial role in glycosylation, a process essential for various cellular functions, including cell adhesion, signaling, and immune response. Dysregulation of B3GALT1 expression has been implicated in cancer progression, making it a promising target for therapeutic interventions. Understanding the function and regulation of B3GALT1 can provide valuable insights into the mechanisms underlying oncogenesis and potentially lead to the development of novel anti-cancer strategies.
Antibody Name:
B3GALT1 Antibody
Antibody SKU:
PACO01738
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Beta-1,3-Gal-T1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
NCBI Summary:
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is expressed exclusively in the brain. The encoded protein shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
