The B3GALNT2 Polyclonal Antibody (PACO07960) is a valuable tool for researchers studying the B3GALNT2 protein, an enzyme involved in glycosylation processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the B3GALNT2 protein, this antibody enables precise detection and analysis in various cell types, providing researchers with a reliable tool for investigating glycosylation pathways and their role in various biological processes.
B3GALNT2 is a key enzyme responsible for synthesizing complex glycan structures, playing a crucial role in protein glycosylation and cell recognition processes. Dysregulation of B3GALNT2 expression has been linked to various diseases, including cancer and developmental disorders, making it a promising target for therapeutic interventions. By studying the function of B3GALNT2, researchers can gain insights into the mechanisms underlying these diseases and potentially develop novel treatment strategies targeting glycosylation pathways.
B3GALNT2: Beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.4.1.-; Membrane protein, integral; TransferaseChromosomal Location of Human Ortholog: 1q42.3Cellular Component: Golgi membrane; endoplasmic reticulum; integral to membraneMolecular Function: acetylglucosaminyltransferase activity; acetylgalactosaminyltransferase activity; galactosyltransferase activityBiological Process: protein amino acid O-linked glycosylation; protein amino acid glycosylationDisease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 11
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2013]
