The B2M Polyclonal Antibody (CAB1562) is specifically designed for research involving B2M, a key component of the major histocompatibility complex (MHC) class I molecules. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in a variety of applications, including Western blotting and immunohistochemistry.B2M is essential for the proper functioning of MHC class I molecules, which play a crucial role in the immune system by presenting antigens to T cells. Dysregulation of B2M expression has been implicated in various diseases, including cancer and autoimmune disorders.
The B2M Polyclonal Antibody enables the detection and analysis of B2M protein levels in different cell types, making it an ideal tool for studies in immunology and cancer research.Understanding the role of B2M in immune response modulation and its implications in disease pathogenesis is essential for the development of targeted therapies and immunotherapies. The B2M Polyclonal Antibody provides researchers with a valuable tool to investigate the function and regulation of B2M in various disease contexts.
Product Name:
beta 2 Microglobulin Rabbit Polyclonal Antibody
SKU:
CAB1562
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-119 of human beta 2 Microglobulin (NP_004039.1).
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
Purification Method:
Affinity purification
Gene ID:
567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using beta 2 Microglobulin Rabbit pAb (CAB1562) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
