The B2M Monoclonal Antibody (PAC06243) is a valuable tool for researchers studying B2M, a key protein involved in immune system function and tumor surveillance. This antibody, developed through a proprietary process, specifically targets human B2M and is optimized for use in a variety of applications, including Western blot and immunohistochemistry.B2M, or beta-2 microglobulin, is a critical component of the major histocompatibility complex (MHC) class I molecules, which play a crucial role in presenting antigens to immune cells. Aberrant expression of B2M has been linked to various diseases, including cancer and autoimmune disorders, making it a promising target for therapeutic intervention.
By using the B2M Monoclonal Antibody, researchers can analyze B2M expression in different cell types and tissues, gaining insights into its role in immune regulation and disease progression.With its high specificity and sensitivity, the B2M Monoclonal Antibody offers a reliable tool for investigating the function of B2M in health and disease. Whether studying immune responses, tumor development, or autoimmune conditions, this antibody provides valuable support for research aimed at understanding the complex interactions of the immune system.
Western Blot. Positive WB detected in: Mouse spleen tissue, Mouse stomach tissue. All lanes: B2m antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 14 kDa. Observed band size: 14 kDa.
IHC image of PACO62243 diluted at 1:400 and staining in paraffin-embedded mouse lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Synonyms:
Beta-2-microglobulin, B2m
UniProt Protein Function:
Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
