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B2M Monoclonal Antibody [PAT101F10AT] (CPAB0663)

SKU:
CPAB0663
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT101F10AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

B2M Monoclonal Antibody [PAT101F10AT] (CPAB0663)

The B2M Monoclonal Antibody (CPAB0663) is a valuable tool for researchers studying Beta-2 Microglobulin (B2M) protein, a key component of the major histocompatibility complex I (MHC I) molecule. This antibody, generated in mice, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for a variety of research applications.B2M is essential for the proper function of MHC I molecules in antigen presentation and immune response. Abnormalities in B2M expression have been linked to various diseases, including autoimmune disorders, viral infections, and certain types of cancer.

By targeting the B2M protein, researchers can gain insights into immune system function and the development of potential therapeutic interventions.The CPAB0663 antibody is validated for use in techniques such as Western blotting, immunofluorescence, and immunohistochemistry, providing versatility for researchers in immunology, oncology, and infectious disease fields. Its ability to specifically detect B2M makes it a powerful tool for studying the role of this protein in health and disease.

Product Name:B2M Antibody
Product Sku:CPAB0663
Size:5μg
Host Species:Mouse
Immunogen:Anti-human B2M mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human B2M protein 21-119 amino acids purified from Ecoli.
Clone:PAT101F10AT.
Reactivity:Other bodies
Applications:ELISA, Flow Cytometry
Purification Method:B2M antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2b
Background:Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).
Synonyms:Beta-2-microglobulin, B2M.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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