The AXL Polyclonal Antibody (CAB17874) is a valuable tool for researchers studying the AXL receptor tyrosine kinase, a key player in various cellular processes such as cell growth, survival, and migration. This antibody, generated in rabbits, specifically targets the AXL protein and has been validated for use in Western blot applications, providing reliable and accurate results.AXL is known for its role in cancer progression, metastasis, and drug resistance, making it a promising target for cancer therapy research. By using the AXL Polyclonal Antibody, researchers can detect and analyze AXL expression in different cell types, paving the way for a better understanding of its function in cancer biology.
This antibody is a valuable tool for studying the mechanisms of AXL signaling and its implications in cancer development.Overall, the AXL Polyclonal Antibody is a key asset for scientists investigating the role of AXL in cancer and other diseases, providing insights that could ultimately lead to the development of novel therapeutic strategies targeting AXL signaling pathways.
Product Name:
Axl Rabbit Polyclonal Antibody
SKU:
CAB17874
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 33-449 of human AXL (NP_068713.2).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
ARK; UFO; JTK11; Tyro7; Axl
Positive Sample:
HeLa,SW620,HepG2
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
98kDa
Observed MW:
140kDa
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
Purification Method:
Affinity purification
Gene ID:
558
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Axl Rabbit pAb (CAB17874) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
