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Axl Rabbit Polyclonal Antibody (CAB17874)

SKU:
CAB17874
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
  • Developmental Biology Anti-AXL Antibody CAB17874
  • Developmental Biology Anti-AXL Antibody CAB17874
  • Developmental Biology Anti-AXL Antibody CAB17874
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Axl Rabbit Polyclonal Antibody
SKU:CAB17874
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 33-449 of human AXL (NP_068713.2).
Sequence:EESP FVGN PGNI TGAR GLTG TLRC QLQV QGEP PEVH WLRD GQIL ELAD STQT QVPL GEDE QDDW IVVS QLRI TSLQ LSDT GQYQ CLVF LGHQ TFVS QPGY VGLE GLPY FLEE PEDR TVAA NTPF NLSC QAQG PPEP VDLL WLQD AVPL ATAP GHGP QRSL HVPG LNKT SSFS CEAH NAKG VTTS RTAT ITVL PQQP RNLH LVSR QPTE LEVA WTPG LSGI YPLT HCTL QAVL SDDG MGIQ AGEP DPPE EPLT SQAS VPPH QLRL GSLH PHTP YHIR VACT SSQG PSSW THWL PVET PEGV PLGP PENI SATR NGSQ AFVH WQEP RAPL QGTL LGYR LAYQ GQDT PEVL MDIG LRQE VTLE LQGD GSVS NLTV CVAA YTAA GDGP WSLP VPLE AWRP GQAQ PVHQ LVKE PSTP AFSW P
Tested Applications:WB IHC-P IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:ARK; UFO; JTK11; Tyro7; Axl
Positive Sample:HeLa,SW620,HepG2
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:98kDa
Observed MW:140kDa

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.

Purification Method:Affinity purification
Gene ID:558
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Axl Rabbit pAb (CAB17874) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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