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Anti-AXIN2 Antibody (CAB17022)

SKU:
CAB17022
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
$167 - $503
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Description

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Anti-AXIN2 Antibody (CAB17022)

The Axin2 Polyclonal Antibody (CAB17022) is a valuable tool for researchers studying the Axin2 protein, which is involved in the Wnt signaling pathway and has important roles in development, tissue homeostasis, and cancer. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications.Axin2 is a key regulator of the Wnt pathway, which plays a critical role in cell proliferation, differentiation, and migration. Dysregulation of this pathway is implicated in various diseases, including cancer. The Axin2 antibody binds specifically to the Axin2 protein, allowing for accurate detection and analysis in various cell types.

Research on Axin2 is essential for understanding its functions in development, stem cell regulation, and tumorigenesis. By studying Axin2 and its interactions with other proteins in the Wnt pathway, researchers can gain insights into potential therapeutic targets for cancer and other diseases. The Axin2 Polyclonal Antibody is a valuable tool for investigating the complex mechanisms of the Wnt signaling pathway and its implications in disease.

Antibody Name:Anti-AXIN2 Antibody
Antibody SKU:CAB17022
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human AXIN2.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW480
Immunogen:A synthetic peptide of human AXIN2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8313
Uniprot:Q9Y2T1
Cellular Location:Cytoplasm
Calculated MW:93kDa
Observed MW:100KDa
Anti-AXIN2 Antibody (CAB17022)Western blot - AXIN2 Rabbit pAb (CAB17022)
Synonyms:AXIN2, AXIL, ODCRCS, axin-2
Background:The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
UniProt Protein Function:axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: nucleoplasm; microtubule cytoskeleton; Golgi apparatus; centrosome; cytoplasmic microtubule; cytoplasm; cytoplasmic membrane-bound vesicle; postsynaptic density; plasma membrane; cell cortex; cytosol; nucleus; beta-catenin destruction complex

Molecular Function:protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity

Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; dorsal/ventral axis specification; negative regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity

Disease: Oligodontia-colorectal Cancer Syndrome

NCBI Summary:The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y2T1
NCBI GenInfo Identifier:12643949
NCBI Gene ID:8313
NCBI Accession:Q9Y2T1.1
UniProt Secondary Accession:Q9Y2T1,Q3MJ88, Q9H3M6, Q9UH84,
UniProt Related Accession:Q9Y2T1
Molecular Weight:843
NCBI Full Name:Axin-2
NCBI Synonym Full Names:axin 2
NCBI Official Symbol:AXIN2  
NCBI Official Synonym Symbols:AXIL; ODCRCS  
NCBI Protein Information:axin-2; conductin; axin-like protein; axis inhibition protein 2
UniProt Protein Name:Axin-2
UniProt Synonym Protein Names:Axin-like protein; Axil; Axis inhibition protein 2; Conductin
Protein Family:Axin
UniProt Gene Name:AXIN2  
UniProt Entry Name:AXIN2_HUMAN

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