The Axin2 Polyclonal Antibody (CAB17021) is a valuable tool for researchers studying the Axin2 protein, a key regulator of the Wnt signaling pathway. This rabbit polyclonal antibody is highly specific and reacts with human samples, making it ideal for applications such as Western blotting and immunofluorescence.Axin2 is a crucial component of the Wnt signaling pathway, which plays a critical role in embryonic development, tissue homeostasis, and cancer progression. Dysregulation of Axin2 expression has been implicated in a variety of diseases, including colorectal cancer, breast cancer, and osteoporosis.By utilizing the Axin2 Polyclonal Antibody, researchers can investigate the expression levels and localization of Axin2 in various cell types and tissues.
This antibody enables precise detection and analysis of Axin2, providing valuable insights into its function and potential as a therapeutic target in cancer and other diseases.Overall, the Axin2 Polyclonal Antibody (CAB17021) is an essential tool for researchers interested in elucidating the role of the Wnt signaling pathway and its implications in disease pathology. Its high specificity and reactivity make it a reliable choice for studying Axin2 in both basic research and clinical applications.
Product Name:
AXIN2 Rabbit Polyclonal Antibody
SKU:
CAB17021
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human AXIN2 (NP_004646.3).
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Purification Method:
Affinity purification
Gene ID:
8313
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AXIN2 Rabbit pAb (CAB17021) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
