AXIN2 Rabbit Polyclonal Antibody (CAB17021)
- SKU:
- CAB17021
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | AXIN2 Rabbit Polyclonal Antibody |
SKU: | CAB17021 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human AXIN2 (NP_004646.3). |
Sequence: | EDEE REGS ELTL NSRE GAPT QHPL SLLP SGSY EEDP QTIL DDHL SRVL KTPG CQSP GVGR YSPR SRSP DHHH HHHS QYHS LLPP GGKL PPAA ASPG ACPL L |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | AXIL; ODCRCS; AXIN2 |
Positive Sample: | Mouse brain,Rat brain |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 94kDa |
Observed MW: | 110kDa |
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Purification Method: | Affinity purification |
Gene ID: | 8313 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |