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AXIN2 Polyclonal Antibody

SKU:
CAB21674
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IF
$155 - $431
Frequently bought together:

Description

AXIN2 Polyclonal Antibody (CAB21674)

The Axin2 Polyclonal Antibody is a key tool for researchers studying the Axin2 protein, which plays a crucial role in the Wnt signaling pathway. This antibody, raised in rabbits, is highly specific to human samples and has been validated for Western blot applications. By binding to the Axin2 protein, this antibody allows for the precise detection and analysis of Axin2 expression in various cell types.Axin2 is an important regulator of cell proliferation and differentiation, making it a target of interest in cancer research and developmental biology.

Its involvement in the Wnt signaling pathway also suggests its potential role in stem cell maintenance and tissue homeostasis. Research on Axin2 has the potential to provide valuable insights into various diseases, including cancer and developmental disorders.By utilizing the Axin2 Polyclonal Antibody, researchers can gain a better understanding of the functions and mechanisms of Axin2, paving the way for potential therapeutic interventions targeting this protein in various disease contexts.

Product Name:AXIN2 Polyclonal Antibody
Product Code:CAB21674
Reactivity:Human
Applications:Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:IF/ICC, ELISA
Key Applications:Immunofluorescence
Recommended Dilution:IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 700-800 of human AXIN2 (NP_004646.3).
Sequence:ACRRL AEVSK PPKQR CCVAS QQRDR NHSAT VQTGA TPFSN PSLAP EDHKE PKKLA GVHAL QASEL VVTYF FCGEE IPYRR MLKAQ SLTLG HFKEQ LSKKG N
Synonyms:AXIL, ODCRCS
Calculated MW:94kDa
Observed MW:Refer to figures

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