AXIN1 Rabbit Polyclonal Antibody (CAB16019)
- SKU:
- CAB16019
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | AXIN1 Rabbit Polyclonal Antibody |
SKU: | CAB16019 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human AXIN1 (NP_851393.1). |
Sequence: | MNIQ EQGF PLDL GASF TEDA PRPP VPGE EGEL VSTD PRPA SYSF CSGK GVGI KGET STAT PRRS DLDL GYEP EGSA SPTP PYLK WAES LHSL LDDQ DGIS LFRT FLKQ EGCA DLLD FWFA CTGF RKLE PCDS NEEK RLKL ARAI YRKY ILDN NGIV SRQT KPAT KSFI KGCI MKQL IDPA MFDQ AQTE IQAT MEEN TYPS FLKS DIYL EYTR TGSE SPKV CSDQ SSGS GTGK GISG YLPT LNED EEWK CDQD MDED DGRD AAPP GRLP QKLL LETA APRV SSSR RYSE GREF RYGS WREP VNPY YVNA GYAL APAT SAND SEQQ SLSS DADT LSLT DSSV DGIP PYRI RKQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | AXIN; PPP1R49; AXIN1 |
Positive Sample: | A-549,mouse kidney,rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Membrane, Nucleus. |
Calculated MW: | 96kDa |
Observed MW: | 110kDa |
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8312 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |