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Axin1 Monoclonal Antibody [PAT1A4AT] (CPAB0435)

SKU:
CPAB0435
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT1A4AT
Applications:
WB
IF
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

Axin1 Monoclonal Antibody [PAT1A4AT] (CPAB0435)

The Axin1 Polyclonal Antibody (CPAB0435) is a cutting-edge tool for researchers studying Axin1, a key protein in the Wnt signaling pathway that regulates cell growth and differentiation. This antibody, generated in rabbits, exhibits high specificity for Axin1 in human samples and has been validated for use in Western blotting applications. By binding specifically to Axin1, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in cell biology and cancer research.Axin1 is a crucial component of the Wnt signaling pathway, acting as a negative regulator to control cell proliferation and tissue development.

Dysregulation of Axin1 signaling has been implicated in various diseases, including cancer and developmental disorders, highlighting its importance as a therapeutic target. Investigating the role of Axin1 in cellular processes is key to uncovering potential treatment strategies for these conditions.Overall, the Axin1 Polyclonal Antibody offers researchers a reliable tool to explore the functions of Axin1 and its impact on cellular pathways, paving the way for new insights into disease mechanisms and potential therapeutic interventions.

Product Name:Axin1 Antibody
Product Sku:CPAB0435
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Axin1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Axin1 amino acids 546-752 purified from Ecoli.
Clone:PAT1A4AT.
Reactivity:Other bodies
Applications:Western Blot, Immunofluorescence, ELISA
Purification Method:Axin1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:AXIN1 is a cytoplasmic protein, which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. Axin1 is has been characterized as a tumor suppressor. In addition, Axin1 has an essential role in the formation of the embryonic neural axis. It has also been reported that Axin is found in mitotic spindles and centrosomes. AXIN1 interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. AXIN1 functions as a negative regulator of the WNT1 signaling pathway and is able to induce apoptosis. Axin can be identified in a mouse mutant strain, created by random integration of a transgene. Mutations in the AXIN1 gene are linked to hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas.
Synonyms:Axin-1, Axis inhibition protein 1, hAxin, AXIN1, AXIN, MGC52315.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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