UniProt Protein Function: | DGAT2L3: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). Belongs to the diacylglycerol acyltransferase family.Protein type: EC 2.3.1.75; Membrane protein, integral; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: Xq13.1Cellular Component: endoplasmic reticulum membraneMolecular Function: long-chain-alcohol O-fatty-acyltransferase activityBiological Process: arachidonic acid metabolic process; wax biosynthetic process |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q58HT5 |
NCBI GenInfo Identifier: | 61888902 |
NCBI Gene ID: | 158833 |
NCBI Accession: | NP_001013597.1 |
UniProt Secondary Accession: | Q58HT5,Q5JT21, Q6IEE4 |
UniProt Related Accession: | Q58HT5 |
Molecular Weight: | 37,759 Da |
NCBI Full Name: | acyl-CoA wax alcohol acyltransferase 1 |
NCBI Synonym Full Names: | acyl-CoA wax alcohol acyltransferase 1 |
NCBI Official Symbol: | AWAT1Â Â |
NCBI Official Synonym Symbols: | DGA2; DGAT2L3Â Â |
NCBI Protein Information: | acyl-CoA wax alcohol acyltransferase 1 |
UniProt Protein Name: | Acyl-CoA wax alcohol acyltransferase 1 |
UniProt Synonym Protein Names: | Diacylglycerol O-acyltransferase 2-like protein 3; Diacylglycerol acyltransferase 2; Long-chain-alcohol O-fatty-acyltransferase 1 |
Protein Family: | Acyl-CoA wax alcohol acyltransferase |
UniProt Gene Name: | AWAT1Â Â |
UniProt Entry Name: | |