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AVPR2 Rabbit Polyclonal Antibody (CAB7879)

SKU:
CAB7879
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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AVPR2 Rabbit Polyclonal Antibody (CAB7879)

The AVPR2 Polyclonal Antibody (CAB7879) is a valuable tool for researchers studying the vasopressin receptor 2 (AVPR2), a key player in regulating water reabsorption in the kidneys and influencing blood pressure. This antibody, produced in rabbits, is highly specific to human AVPR2 and has been validated for use in Western blot applications.AVPR2 is known for its role in the regulation of water balance in the body, making it an important target for studies in physiology, nephrology, and endocrinology. Dysregulation of AVPR2 function has been linked to various conditions including diabetes insipidus and other water balance disorders, making this antibody a valuable asset for research in these areas.

By enabling the detection and analysis of AVPR2 protein expression in different cell types, the AVPR2 Polyclonal Antibody (CAB7879) opens up opportunities for further understanding of its role in health and disease. Its high reactivity and specificity make it an ideal choice for researchers looking to advance their knowledge of AVPR2 function and its potential as a therapeutic target.

Product Name:AVPR2 Rabbit Polyclonal Antibody
SKU:CAB7879
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 232-371 of human AVPR2 (NP_000045.1).
Sequence:IHAS LVPG PSER PGGR RRGR RTGS PGEG AHVS AAVA KTVR MTLV IVVV YVLC WAPF FLVQ LWAA WDPE APLE GAPF VLLM LLAS LNSC TNPW IYAS FSSS VSSE LRSL LCCA RGRT PPSL GPQD ESCT TASS SLAK DTSS
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:DI1; DIR; NDI; V2R; ADHR; DIR3; NDI1; AVPR2
Positive Sample:293T,COS-1
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Multi-pass membrane protein.
Calculated MW:40kDa
Observed MW:46kDa

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.

Purification Method:Affinity purification
Gene ID:554
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using AVPR2 Antibody (CAB7879) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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