The AVPR1B Polyclonal Antibody (PACO7400) is a valuable tool for researchers studying the vasopressin receptor 1B (AVPR1B), a G protein-coupled receptor involved in regulating stress responses and social behavior. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the AVPR1B protein, this antibody facilitates the detection and analysis of this receptor in various cell types, making it ideal for research in neurobiology, endocrinology, and psychology.
AVPR1B is known for its role in modulating the release of stress hormones and regulating social interactions, making it a key player in conditions such as anxiety, depression, and social bonding. Understanding the function of AVPR1B is crucial for unraveling the mechanisms underlying these complex behaviors and developing targeted therapies for related disorders. With its specificity and sensitivity, the AVPR1B Polyclonal Antibody is a valuable tool for investigating the role of this receptor in health and disease.
Antibody Name:
AVPR1B Antibody (PACO07400)
Antibody SKU:
PACO07400
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000-1:20000, IHC-p:1:50-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide from human protein at AA range: 271-320
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
AVPR1B: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
UniProt Protein Details:
Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: endosome; integral to plasma membrane; plasma membrane
Molecular Function:peptide binding; protein kinase C binding
Biological Process: cellular response to hormone stimulus; elevation of cytosolic calcium ion concentration; phospholipase C activation; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin
NCBI Summary:
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
