The AVP Polyclonal Antibody (CAB1725) is a valuable tool for researchers studying vasopressin (arginine vasopressin, AVP), a hormone involved in regulating water balance and blood pressure in the body. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various experimental techniques, including Western blotting.Vasopressin is a key player in the body's response to changes in hydration status and is also involved in functions such as stress response, social behavior, and memory formation.
The AVP Polyclonal Antibody binds specifically to the AVP molecule, allowing for detection and analysis of this important hormone in different cell types and tissues.Research into vasopressin's role in conditions such as diabetes insipidus, hypertension, and related disorders relies on tools like the AVP Polyclonal Antibody to accurately measure levels of this hormone. Understanding the mechanisms by which vasopressin acts in the body can lead to potential therapeutic interventions for these conditions.
Product Name:
AVP Rabbit Polyclonal Antibody
SKU:
CAB1725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-164 of human AVP (NP_000481.2).
Sequence:
CYFQ NCPR GGKR AMSD LELR QCLP CGPG GKGR CFGP SICC ADEL GCFV GTAE ALRC QEEN YLPS PCQS GQKA CGSG GRCA AFGV CCND ESCV TEPE CREG FHRR ARAS DRSN ATQL DGPA GALL LRLV QLAG APEP FEPA QPDA Y
This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20.
Purification Method:
Affinity purification
Gene ID:
551
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AVP Rabbit pAb (CAB1725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
