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AURKB/AURKC Antibody (PACO00446)

SKU:
PACO00446
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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AURKB/AURKC Antibody (PACO00446)

The AURKB/AURKC Polyclonal Antibody (PACO00446) is a vital tool for researchers studying Aurora kinases B and C, key regulators of cell division and mitosis. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting these proteins in human samples, making it an essential component in Western blot experiments.Aurora kinases are pivotal players in cell cycle progression, ensuring accurate segregation of chromosomes during cell division. Dysregulation of these kinases has been linked to various diseases, including cancer, making them attractive targets for therapeutic intervention.

By using the AURKB/AURKC Polyclonal Antibody, researchers can gain insights into the role of these kinases in tumorigenesis and potentially identify new avenues for cancer treatment.In summary, the AURKB/AURKC Polyclonal Antibody offers researchers a reliable tool to investigate the functions of Aurora kinases B and C in cell biology and disease. Its high specificity and sensitivity make it a valuable asset in advancing our understanding of cell division mechanisms and identifying potential targets for therapeutic intervention.

Antibody Name:AURKB/AURKC Antibody
Antibody SKU:PACO00446
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human ARK-2/3 around the non-phosphorylation site of T236/202.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:AURKB; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; Aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12
UniProt Protein Function:AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Other group; AUR family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: chromocenter; condensed nuclear chromosome, pericentric region; cytosol; intercellular bridge; kinetochore; midbody; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function:ATP binding; histone serine kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: abscission; aging; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; attachment of spindle microtubules to kinetochore; cell proliferation; cellular protein metabolic process; histone modification; mitotic cell cycle; negative regulation of B cell apoptosis; negative regulation of cytokinesis; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytokinesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; post-translational protein modification; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein sumoylation; regulation of chromosome segregation; small GTPase mediated signal transduction; spindle checkpoint; spindle midzone assembly involved in mitosis; spindle stabilization

NCBI Summary:This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q96GD4
NCBI GenInfo Identifier:317373473
NCBI Gene ID:9212
NCBI Accession:Q96GD4.3
UniProt Secondary Accession:Q96GD4,O14630, O60446, O95083, Q96DV5, Q9UQ46, B4DNM4 C7G533, C7G534, C7G535, D3DTR4, J9JID1,
UniProt Related Accession:Q96GD4
Molecular Weight:39,467 Da
NCBI Full Name:Aurora kinase B
NCBI Synonym Full Names:aurora kinase B
NCBI Official Symbol:AURKB  
NCBI Official Synonym Symbols:AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2  
NCBI Protein Information:aurora kinase B
UniProt Protein Name:Aurora kinase B
UniProt Synonym Protein Names:Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B
Protein Family:Aurora kinase
UniProt Gene Name:AURKB  
UniProt Entry Name:AURKB_HUMAN

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