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AURKB Monoclonal Antibody [PAT2B1AT] (CPAB0099)

SKU:
CPAB0099
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PAT2B1AT
Applications:
IF
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

AURKB Monoclonal Antibody [PAT2B1AT] (CPAB0099)

The AURKB Polyclonal Antibody (CPAB0099) is a research tool designed for the detection and analysis of Aurora B kinase (AURKB), a key regulator of cell division and mitosis. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. AURKB is a critical player in the cell cycle and is involved in ensuring proper chromosome segregation during mitosis. Dysregulation of AURKB has been linked to cancer development and progression, making it an attractive target for cancer research. By targeting AURKB, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially develop novel treatment strategies.

This polyclonal antibody binds specifically to AURKB, allowing for accurate detection and quantification in various cell types. Its high specificity and sensitivity make it an invaluable tool for studying the role of AURKB in cell division, cancer biology, and therapeutic development. Researchers in the fields of oncology, cell biology, and drug discovery will find the AURKB Polyclonal Antibody (CPAB0099) to be a valuable asset in their studies.

Product Name:AURKB Antibody
Product Sku:CPAB0099
Size:5μg
Host Species:Mouse
Immunogen:Anti-human AURKB mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human AURKB amino acids 1-344 purified from Ecoli.
Clone:PAT2B1AT.
Reactivity:Human
Applications:Immunofluorescence, ELISA
Purification Method:AURKB antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation, while overexpression is seen in many kinds of cancers. AURKB phosphorylates ''Ser-10'' and ''Ser-28'' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex), which is a complex that acts as a key regulator of mitosis. High level expression of AURKB is seen in the thymus, which is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
Synonyms:Serine/threonine-protein kinase 12, Aurora kinase B, Serine/threonine-protein kinase aurora-B, Aurora- and Ipl1-like midbody-associated protein 1, Aurora/IPL1-related kinase 2, Aurora-related kinase 2, AIM-1, ARK-2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12, AurB, IPL1, STK5, aurkb-sv1, aurkb-sv2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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