The AURKA/IP1 Polyclonal Antibody (PACO15813) is a valuable tool for researchers studying the AURKA/IP1 protein, a key regulator of cell division and proliferation. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By binding specifically to the AURKA/IP1 protein, this antibody enables researchers to detect and analyze protein expression in various cell types, providing insights into its role in cancer and other diseases.
AURKA/IP1, also known as Aurora kinase A-interacting protein 1, plays a crucial role in cell cycle progression and mitosis, making it a promising target for cancer therapy. Dysregulation of AURKA/IP1 has been implicated in a variety of cancers, highlighting its potential as a therapeutic target. By studying the function of AURKA/IP1 using this antibody, researchers can gain a better understanding of its role in cancer development and progression, ultimately leading to the development of targeted treatments.
Antibody Name:
AURKAIP1 Antibody (PACO15813)
Antibody SKU:
PACO15813
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Fusion protein of human AURKAIP1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO15813(AURKAIP1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid, protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, ParkinsonÂ’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Synonyms:
aurora kinase A interacting protein 1
UniProt Protein Function:
AKIP: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 1p36.33Cellular Component: nucleoplasm; mitochondrion; intracellular membrane-bound organelle; mitochondrial inner membrane; nucleusMolecular Function: protein bindingBiological Process: mitochondrial translation; positive regulation of proteolysis; organelle organization and biogenesis; negative regulation of mitosis
