UniProt Protein Function: | AUP1: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; Endoplasmic reticulumChromosomal Location of Human Ortholog: 2p13Cellular Component: integral to endoplasmic reticulum membrane; membraneMolecular Function: protein binding; ubiquitin bindingBiological Process: ER-associated protein catabolic process; retrograde protein transport, ER to cytosol |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
UniProt Code: | Q9Y679 |
NCBI GenInfo Identifier: | 12643958 |
NCBI Gene ID: | 550 |
NCBI Accession: | Q9Y679.1 |
UniProt Secondary Accession: | Q9Y679,Q9H866, Q9UNQ6, Q9Y685, C0H5W8 |
UniProt Related Accession: | Q9Y679 |
Molecular Weight: | 41,385 Da |
NCBI Full Name: | Ancient ubiquitous protein 1 |
NCBI Synonym Full Names: | ancient ubiquitous protein 1 |
NCBI Official Symbol: | AUP1Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | ancient ubiquitous protein 1 |
UniProt Protein Name: | Ancient ubiquitous protein 1 |
UniProt Synonym Protein Names: | |
Protein Family: | Ancient ubiquitous protein |
UniProt Gene Name: | AUP1Â Â |
UniProt Entry Name: | AUP1_HUMAN |