Ataxin 3 Rabbit Polyclonal Antibody (CAB12992)
- SKU:
- CAB12992
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Ataxin 3 Rabbit Polyclonal Antibody |
SKU: | CAB12992 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human Ataxin-3 (ATXN3) (NP_004984.2). |
Sequence: | MESI FHEK QEGS LCAQ HCLN NLLQ GEYF SPVE LSSI AHQL DEEE RMRM AEGG VTSE DYRT FLQQ PSGN MDDS GFFS IQVI SNAL KVWG LELI LFNS PEYQ RLRI DPIN ERSF ICNY KEHW FTVR KLGK QWFN LNSL LTGP ELIS DTYL ALFL AQLQ QEGY SIFV VKGD LPDC EADQ LLQM IRVQ QMHR PKLI GEEL AQLK EQRV HKTD LERV LEAN DGSG MLDE DEED LQRA LALS RQEI DMED EEAD LRRA IQLS MQGS SRNI SQDM TQTS GTNL TSEE LRKR REAY FEKQ QQKQ QQQQ QQQQ QGDL SGQS SHPC ERPA TSSG ALGS DLGD AMSE EDML QAAV TMSL ETVR NDLK TEGK K |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | AT3; JOS; MJD; ATX3; MJD1; SCA3; Ataxin-3 (ATXN3) |
Positive Sample: | MCF7,SW480,Jurkat,A-549,DU145,Mouse brain,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus matrix. |
Calculated MW: | 41kDa |
Observed MW: | 50kDa |
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4287 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |